Both sides will compete in Group A, sharing the section with South Korea and Czechia.
Mexico have the benefit of playing all three of their group stage matches at home and will be eager to capitalise on that advantage.
Confidence should be high in the Mexico camp after extending their unbeaten streak to eight matches with an emphatic 5-1 friendly victory over Serbia last week.
For South Africa, this is their first taste of World Cup action since they welcomed the tournament to their shores in 2010.
Hugo Broos’ men have struggled for momentum since securing qualification, suffering a round of 16 exit at the Africa Cup of Nations and failing to win any of their next four friendly matches.
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